TABLE 1.

Effects of TAK-457 and reference antifungal agents on lung weight and fungal burden in lungs of neutropenic CDF₁ mice inoculated intranasally with A. fumigatus 437^a

Drug	Dose (mg/kg)	No. of surviving mice/total no. of mice	Mean ± SEMb
			Lung wt (mg)	Fungal burden in lungs (log CFU/g)
Vehicle	0	5/15	420 ± 29.6	5.07 ± 0.07
TAK-457	3	6/8	381 ± 21.9	4.65 ± 0.14
TAK-457	10	8/8	299 ± 46.1**	3.12 ± 0.27**
Fluconazole	10	5/8	387 ± 13.4	5.07 ± 0.06
Amphotericin B	1	8/8	295 ± 11.3**	4.16 ± 0.19*

^aAntifungal agents were administered intravenously once a day on days 0, 1, and 2 of infection, and the weight and the number of A. fumigatus cells were determined for the surviving mice on day 3.

^b*, P < 0.05; **, P < 0.01 (versus the vehicle-treated group).