TABLE 2.
Effects of TAK-457 and reference antifungal agents on lung weight and fungal burden in lungs of neutropenic CBA/J mice inoculated intranasally with A. fumigatus 437a
| Drug | Dose (mg/kg) | No. of surviving mice/total no. of mice | Mean ± SEMb
|
|
|---|---|---|---|---|
| Lung wt (mg) | Fungal burden in lungs (log CFU/g) | |||
| Vehicle | 0 | 8/8 | 264 ± 16.8 | 4.50 ± 0.07 |
| TAK-457 | 10 | 8/8 | 196 ± 6.57* | 4.37 ± 0.03 |
| Amphotericin B | 1 | 8/8 | 202 ± 7.75* | 4.47 ± 0.08 |
a
Antifungal agents were administered intravenously once a day on days 0 and 1 of infection, and the weight and the number of A. fumigatus cells were examined for surviving mice on day 2.
b
*, P < 0.01 versus the vehicle-treated group.