FIG. 1.

Grepafloxacin transport in intestinal isolated tissue from SDRs and EHBRs and mounted in Ussing chambers. The transport of grepafloxacin (1 μM) across the intestinal tissue was evaluated from the time course of transport by the Ussing chamber method. The experimental solution was adjusted to pH 7.4, and the temperature was maintained at 37°C. Circles and squares, transport in SDRs and EHBRs, respectively; open and closed symbols, m-s and s-m, respectively. Each point represents the mean ± SE of four to seven experiments.