FIG. 2.
Time courses of the concentrations of [14C]grepafloxacin in plasma after i.v. administration to SDRs and EHBRs. [14C]grepafloxacin (34 nmol) dissolved in saline solution was administered intravenously to SDRs (open circles) or EHBRs (closed circles). Serial blood samples were collected from the carotid artery of individual rats via a cannula at designated time intervals over the experimental period. Each point represents the mean ± standard error of the mean for four to six animals. *, significant difference between SDRs and EHBRs by Student’s t test (P < 0.05).