TABLE 1.

Inhibitory effects of P-gp and MRP2 modulators on grepafloxacin transport in isolated SDR intestinal tissue mounted in an Ussing chamber^a

Treatment	Permeability coefficient (μl/cm2/min)		Net secretion (μl/cm2/min) [(s-m) − (m-s)]	Secretory ratio [(s-m)/(m-s)]
	m-s	s-m
Control	0.759 ± 0.100	3.25 ± 0.48	2.49 ± 0.40	4.32 ± 0.36
Cyclosporine (10 μM)	1.03 ± 0.14	1.90 ± 0.52b	0.861 ± 0.266b	2.03 ± 0.42b
Probenecid (1 mM)	1.13 ± 0.18	1.80 ± 0.20b	0.667 ± 0.185b	1.75 ± 0.24b
Cyclosporine (10 μM) + probenecid (1 mM)	0.515 ± 0.029	0.905 ± 0.035b	0.390 ± 0.055b	1.80 ± 0.14b

^aThe time course of grepafloxacin (10 μM) transport across the intestinal tissue was evaluated. The modulators were added to the donor solution. The experimental solution was adjusted to pH 7.4, and the temperature was maintained at 37°C.

^bSignificantly different from control value by Student’s t test (P < 0.05).