TABLE 2.
Antibiotic resistance patterns, quinolone susceptibilities, and substitutions in the GyrA and ParC QRDRs for strains of the A. caviae complex
| A. caviae strain | Antibiotic resistance patterna | Quinolone MICb (mg/liter)
|
Amino acid in QRDRs
|
|||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| GyrA
|
ParC
|
|||||||||||||||||
| NAL | OA | PI | UB | NOR | PEF | OFX | SPX | CIP | ENR | Position 83 | Position 92 | Position 80 | Position 84 | |||||
| CIP 7616 | 0.2 | ≤0.1 | ≤0.1 | 0.02 | ≤0.001 | ≤0.001 | ≤0.001 | ≤0.001 | ≤0.001 | 0.005 | Ser | Met | Ser | Glu | ||||
| 4 | ≤0.1 | ≤0.1 | ≤0.1 | ≤0.01 | 0.002 | ≤0.001 | ≤0.001 | ≤0.001 | 0.002 | 0.002 | ||||||||
| 242 | Q | 128 | 1 | 8 | 2 | 0.2 | 0.5 | 0.2 | 0.2 | 0.05 | 0.1 | Arg | ||||||
| 94 | Q | 128 | 8 | 128 | 16 | 2 | 2 | 1 | 0.5 | 0.5 | 1 | Ile | Lys | |||||
| 100 | Q | >512 | 32 | 256 | 512 | 4 | 16 | 4 | 4 | 1 | 4 | Ile | Leu | Ile | ||||
| 542 | Q, Ctx, (Tc), (C) | 128 | 4 | 16 | 4 | 4 | 4 | 1 | 1 | 1 | 0.5 | Arg | ||||||
| 33 | Q, Ctx, Sxt, KGT | 128 | 8 | 128 | 16 | 4 | 4 | 2 | 2 | 1 | 2 | Ile | Arg | |||||
| 2 | Q, Tc, (C), (Sxt), T | 512 | 32 | 64 | 64 | 4 | 2 | 1 | 4 | 0.5 | 2 | Ile | Ile | |||||
| 495 | Q, (Tc), Fos | >512 | 8 | 32 | 8 | 4 | 1 | 0.5 | 1 | 0.1 | 1 | Ile | ||||||
| 198 | Q, (Tc) | >512 | 32 | 128 | 512 | 16 | 16 | 2 | 2 | 4 | 4 | Ile | Leu | Lys | ||||
a
Q, quinolones; Ctx, cefotaxime; Tc, tetracycline; C, chloramphenicol; Sxt, co-trimoxazole; K, kanamycin; G, gentamicin; T, tobramycin; Fos, fosfomycin; parentheses indicate low-level resistance.
b
NAL, nalidixic acid; OA, oxolinic acid; PI, pipemidic acid; UB, flumequine; NOR, norfloxacin; PEF, pefloxacin; OFX, ofloxacin; SPX, sparfloxacin; CIP, ciprofloxacin; ENR, enrofloxacin.