TABLE 1.

Effects of carbapenems in combination with EGCg against 24 MRSA isolates

Combination	MIC50 (μg/ml)a of combination	% of MRSA isolates showing indicated effect:
		Synergistic	Additive	None	MIC of ≤4 μg/mlb
EGCg 1.56 μg/ml
IPM	64	0	46	54	0
PAPM	32	4	33	63	4
MEM	64	0	42	58	0
EGCg 3.125 μg/ml
IPM	32	42	41	17	8
PAPM	16	29	63	8	21
MEM	32	38	62	0	4
EGCg 6.25 μg/ml
IPM	8	83	17	0	38
PAPM	8	75	17	8	46
MEM	8	83	17	0	25
EGCg 12.5 μg/ml
IPM	8	88	12	0	46
PAPM	2	83	9	8	67
MEM	8	88	12	0	42
EGCg 25 μg/ml
IPM	0.25	92	8	0	75
PAPM	0.5	88	12	0	75
MEM	2	83	17	0	71

^aMICs at which 50% of the isolates treated with carbapenem alone are inhibited: IPM, 128 μg/ml; PAPM 32 μg/ml; MEM, 64 μg/ml.

^bMIC susceptibility breakpoint is ≤4 μg/ml for IPM and MEM, as determined by NCCLS, but is not available for PAPM at present.