TABLE 1.
MICs of SS750, FLC, ITC, and AMB for Candida species and C. neoformansa
| Organism (no. of strains) and drug | MIC (μg/ml)
|
||
|---|---|---|---|
| Range | 50% | 90% | |
| C. albicans (55) | |||
| SS750 | 0.031–0.25 | 0.063 | 0.125 |
| FLC | 0.125–2 | 0.25 | 0.5 |
| ITC | ≤0.008–0.125 | 0.031 | 0.063 |
| AMB | 0.25–0.5 | 0.5 | 0.5 |
| Fluconazole-resistant C. albicans (6)b | |||
| SS750 | 0.5–>16 | 1 | >16 |
| FLC | 16–>64 | 32 | >64 |
| ITC | 0.5–>8 | 0.5 | >8 |
| AMB | 0.5–1 | 0.5 | 1 |
| C. tropicalis (17) | |||
| SS750 | 0.031–0.5 | 0.063 | 0.5 |
| FLC | 0.25–4 | 1 | 2 |
| ITC | 0.016–0.25 | 0.063 | 0.125 |
| AMB | 0.25–1 | 0.5 | 0.5 |
| C. parapsilosis (15) | |||
| SS750 | ≤0.016–0.5 | 0.125 | 0.25 |
| FLC | 0.25–8 | 2 | 8 |
| ITC | 0.016–0.25 | 0.125 | 0.25 |
| AMB | 0.5–1 | 1 | 1 |
| C. guilliermondii (14) | |||
| SS750 | ≤0.016–1 | 0.125 | 1 |
| FLC | 0.25–8 | 4 | 4 |
| ITC | 0.016–0.5 | 0.25 | 0.5 |
| AMB | 0.125–1 | 0.5 | 0.5 |
| C. kefyr (9) | |||
| SS750 | 0.031–0.063 | 0.031 | 0.063 |
| FLC | 0.25–0.5 | 0.5 | 0.5 |
| ITC | 0.016–0.25 | 0.063 | 0.25 |
| AMB | 0.25–1 | 0.5 | 1 |
| C. krusei (16) | |||
| SS750 | 0.25–1 | 0.5 | 1 |
| FLC | 16–>64 | 64 | 64 |
| ITC | 0.063–0.5 | 0.25 | 0.5 |
| AMB | 0.5–1 | 1 | 1 |
| C. glabrata (14) | |||
| SS750 | 0.063–4 | 1 | 2 |
| FLC | 0.5–64 | 16 | 64 |
| ITC | 0.031–4 | 1 | 4 |
| AMB | 0.125–0.5 | 0.5 | 0.5 |
| C. neoformans (26) | |||
| SS750 | 0.125–2 | 0.5 | 2 |
| FLC | 1–16 | 4 | 8 |
| ITC | 0.031–0.5 | 0.125 | 0.25 |
| AMB | 0.25–1 | 0.5 | 1 |
a
MICs were determined by the broth microdilution method according to NCCLS method M27-A (14).
b
Three resistant and three dose-dependent susceptible strains, on the basis of NCCLS breakpoints for FLC resistance in C. albicans, were included.