TABLE 3.

Correlation of specific mutations with rifampin MICs^a

Strain	Rifampin MIC (μg/ml)	Mutation	Mutation type	Amino acid change
ICC221	10	G1317A	Novel	L521L
ICC208, ICC205	10	A1304T	Reported	D516V
ICC37	10	A1304G	Reported	D516G
ICC204	40	G1317A	Novel	L521L
ICC204	40	G1336T	Novel	K527N
ICC105	40	G1336T	Novel	K527N
ICC129	40	G1338C	Novel	R528P
ICC131	40	C1331T	Reported	H526Y
ICC131	40	G1338C	Novel	R528P
ICC123	64	G1338C	Novel	R528P
ICC100	64	C1349T	Reported	S531L
ICC213	64	G1340A	Novel	R528H
ICC213	64	C1349G	Reported	S531W
ICC218	64	T1321C	Novel	S522Q
ICC218	64	C1322A	Novel	S522Q
ICC257	64	G1287T	Novel	Q510H
ICC257	64	C1288T	Novel	L511L
ICC275	64	C1333T	Reported	H526Y
ICC220	64	C1349G	Reported	S531W
ICC128	128	C1331T	Reported	H526Y
ICC128	128	G1338A	Novel	R528H

^aMissense mutations in the RpoB protein at amino acid positions 510, 511, 522, 526, 527, 528, and 531 confer higher levels of resistance (MICs, ≥40 μg/ml) than those at positions 509, 516, and 521 (MICs, ≤10 μg/ml).