. 2002 Feb;46(2):590–593. doi: 10.1128/AAC.46.2.590-593.2002

TABLE 2.

MICs and mutations observed in 41-91 mutants selected after 10 passages in enrofloxacin

Strain	MIC (μg/ml)^a									Mutations in QRDRs of^b:
	MIC (μg/ml)^a									GyrA		GyrB		ParC				ParE
	ENR	CIP	OFX	MAR	DAN	DIF	NOR	OA	UB	83	87	426	465	64	80	81	84	420	463
Parent	0.06	0.03	0.06	0.06	0.06	0.125	0.25	4	2	Ser	Glu	Asp	Glu	Ala	Ser	Ser	Glu	Asp	Ser
41M1	0.125	0.125	0.125	0.125	0.125	0.125	0.25	4	8			Asn
41M2	0.25	0.5	1	1	0.5	0.25	4	8	16			Asn				Pro
41M3	0.5	0.25	2	1	0.5	0.5	2	8	32			Asn						Asn
41M4	1	2	1	1	2	2	4	16	32			Asn				Pro			Leu
41M5	2	0.5	2	2	1	1	2	8	16		Lys	Asn						Asn
41M6	2	1	1	1	2	4	4	16	32	Ile		Asn				Pro
41M7	2	2	4	2	1	2	4	16	16	Ile		Asn							Leu
41M8	2	4	8	4	2	4	8	32	32	Asn		Asn					Gln		Leu
41M9	8	8	16	16	2	8	4	32	32	Arg		Asn				Pro
41M10	8	8	8	8	2	4	8	16	16	Ile		Asn		Ser			Gly		Leu
41M11	16	16	32	32	2	8	32	16	32	Ile	Lys							Lys
41M12	16	16	16	16	4	4	8	32	16	Ile		Asn					Gly		Leu
41M13	16	16	16	16	2	8	16	16	32		Lys		Lys		Leu			Asn
41M14	16	16	32	32	4	8	16	16	32	Ile		Asn			Leu				Leu
41M15	16	16	32	64	4	8	16	32	32	Ile		Asn			Trp	Pro
41M16	32	32	16	32	4	8	32	32	32	Arg			Gly		Leu			Asn
41M17	32	32	32	64	4	8	16	32	32	Ile		Asn			Leu	Pro

ENR, enrofloxacin; CIP, ciprofloxacin; OFX, ofloxacin; MAR, marbofloxacin; DAN, danofloxacin; DIF, difloxacin; NOR, norfloxacin; OA, oxolinic acid; and UB, flumequine.

E. coli numbering.