Table 4.
The different targets within H. pylori and their control ligands were used in the study
| Target name | PDB ID | Its function | The control ligand name | Reference for target |
|---|---|---|---|---|
| Urease | 1E9Y |
-Bacterial Survival -Virulence factor |
Acetohydroxamic Acid | [37] |
| Lipoprotein 20 (LPP20; HP 1456) | 5OK8 |
-colonization -pathogenesis |
Mitomycin | [38] |
| Aspartate α-decarboxylase (ADC) enzyme | 1UHE |
-survival -maintain intracellular pH |
Aspartate | [39] |
| S-ribosylhomocysteinase (LuxS) | 1J6X | Works as a signaling molecule crucial for bacterial communication. | - | [40] |
|
GTP cyclohydrolase II (GCH II) |
4RL4 | -survival and colonization | - | [41] |
| Cytotoxin-associated gene A (CagA) | 4dvz | -virulence factor | - | [42] |
| Sialic acid-binding adhesion (SabA) | 4o5j |
-adhesion -pathogenesis |
- | [43] |
| Blood group antigen-binding adhesion (BabA) | 4zh7 |
-adhesion -pathogenesis |
Lewis b antigen | [44] |
| Vacuolating cytotoxin A (VacA) | 2qv3 | -virulence factor | - | [45] |
| fructose-1,6-bisphosphate aldolase (FBA) | 3C56 | -Energy production for survival | 3-(hydroxy[(phosphonooxy) acetyl] amino} propyl dihydrogen phosphate (PH4) | [46] |