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Effect of GM-CSF, TNF-α, or LPS on KNI-272 metabolism in macrophages. Cultures of M/M in medium to which KNI-272 had been added at a final concentration of 10 μM were cultured as as in Fig. 5. Aliquots (250 ml) were withdrawn at days 0, 1, and 2, and the concentration of the remaining KNI-272 was determined as described in Materials and Methods.
