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HIV-1 protease activity in the presence of increasing concentrations of KNI-272 and M1 and M2 (KNI-272 metabolites). Each compound was separated and purified by RP-HPLC. The compounds were dissolved in DMSO and then tested for inhibitory activity toward the HIV-1 protease as described in Materials and Methods. Each point represents the mean of three independent measurements ± the standard deviation. Symbols: ⧫, KNI-272; ▪, M1; and ▴, M2.
