Table 2:

Literature review of reported histologically atypical and malignant nodular fasciitis cases

Study	Age (y)	Sex	Site	Size (cm)	Nuclear pleomorphism/Necrosis	MI (/HPFs)	Atypical mitotic figures	Gene fusion	Treatment	LR/DM	Status at last FU	FU period (mo)
Qiu et al.	1.8	M	Left scapular area	2.6	No/No	10/10	Yes	PAFAH1B1 (exon 1)::USP6 (exon 9)	Resection	No	NED	39
Tomassen et al.	10	M	Chest wall	2.4	Yes/No	Numerous	Yes	COL6A2 (exon 1)::USP6(exon 9)	Resection	No	NED	22
Lenz et al.	41	F	Forearm	2–3	No/No	5/5	Yes	EIF5A (exon 1)::USP6 (exon 1)	Resection	NA	NA	NA
Papke at al.	7	M	Dorsal wrist	2.2	Yes/No	7/10	Yes	CALD1 (exon 3)::USP6 (exon 2)	Resection	NA	NA	NA
Teramura et al.	27	M	Upper arm	6.3	Yes/Yes	5/10	NA	PPP6R3 (exon 1)::USP6 (exon 1)	Resection	No	NED	12
Arcovito et al.	56	M	Shoulder	NA	No/No	Increased	Yes	THBS2::USP6	Resection	No	NED	34
Arcovito et al.	29	F	Thigh	NA	No/No	Increased	Yes	RRBP1::USP6	Resection	No	NED	42
Arcovito et al.	58	M	Thigh	NA	No/No	Increased	Yes	Unknown partner (USP6 rearranged)	Resection	No	NED	38

M, male; F, female; y, year; mo, months; FU, follow-up; NED, no evidence of disease; AWD, alive with disease; LR, local recurrence; DM, distant metastasis; HPF, high-power fields