TABLE 4.
In vitro antimycobacterial activities against SDR M. tuberculosis strains
| Compound | MIC (μg/ml)a for: |
|||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| INH-R | INH-R/H37Rv | RMP-R | RMP-R/H37Rv | EMB-R | EMB-R/H37Rv | KM-R | KM-R/H37Rv | CIP-R | CIP-R/H37Rv | ETA-R | ETA-R/H37Rv | TAC-R | TAC-R/H37Rv | |
| 1b | >1.6 | >32 | 0.05 | 1.00 | 0.05 | 1.00 | NTb | NT | >1.6 | >32 | >1.6 | >32 | ||
| 1c | >6.4 | >128 | ≤0.1 | ≤2 | ≤0.1 | ≤2 | ≤0.1 | ≤2 | 0.2 | 4.00 | NT | NT | ||
| 1e | >3.2 | >32 | 0.1 | 1.00 | 0.1 | 1.00 | 0.1 | 1.00 | 0.39 | 3.90 | NT | NT | ||
| 1h | >3.2 | >32 | 0.2 | 2.00 | 0.2 | 2.00 | NT | NT | 3.2 | 32 | >3.2 | >32 | ||
| 1i | >6.25 | >31.25 | 0.2 | 1.00 | 0.2 | 1.00 | NT | NT | >6.25 | >31.25 | >6.25 | >31.25 | ||
| 1k | >1.6 | >32 | 0.2 | 4.00 | 0.1 | 2.00 | NT | NT | >1.6 | >32 | >1.6 | >32 | ||
| 2a | >6.25 | >31.25 | 0.39 | 1.95 | 0.2 | 1.00 | NT | NT | >6.25 | >31.25 | >6.25 | >31.25 | ||
| 2b | >6.4 | >32 | 0.39 | 1.95 | 0.39 | 1.95 | 0.4 | 2.00 | 0.78 | 3.90 | NT | NT | ||
| 2e | >6.25 | >31.25 | 0.39 | 1.95 | 0.39 | 1.95 | NT | NT | >6.25 | >31.25 | >6.25 | >31.25 | ||
| 2h | >200 | >32 | 12.5 | 2.00 | 6.25 | 1.00 | 6.25 | 1.00 | 25 | 4.00 | NT | NT | ||
| 2i | >50 | >31.25 | 3.13 | 1.96 | 1.56 | 0.98 | 3.13 | 1.96 | 6.26 | 3.91 | NT | NT | ||
| 2k | >50 | >31.25 | 3.13 | 1.96 | ≤0.78 | ≤0.49 | NT | NT | >50 | >31.25 | >50 | >31.25 | ||
| 2l | >50 | >31.25 | 3.13 | 1.96 | ≤0.78 | ≤0.49 | NT | NT | >50 | >31.25 | >50 | >31.25 | ||
| 2n | >50 | >31.25 | 3.13 | 1.96 | ≤0.78 | ≤0.49 | NT | NT | >50 | >31.25 | 50 | 31.25 | ||
| 2p | >12.5 | >32.05 | 0.78 | 2.00 | 0.39 | 1.00 | NT | NT | >12.5 | >32.05 | >12.5 | >32.05 | ||
a
INH-R, INH-resistant strain; RMP-R, rifampin-resistant strain; EMB-R, ethambutol-resistant strain; KM-R, kanamycin-resistant strain; CIP-R, ciprofloxacin-resistant strain; ETA-R, ethionamide-resistant strain; TAC-R, thiacetazone-resistant strain. Ratios of MICs against resistant and nonresistant strains of ≅1 indicate activity also against the resistant strain; larger ratios indicate cross-resistance.
b
NT, not tested.