Table 1.

Comparison of demographic, hematological, and inflammatory parameters between hyperemesis gravidarum (HG) patients and healthy controls

	HG (n = 159)	Control (n = 100)	p value
	Median (IQR)	Median (IQR)
Age (year)	29.00 (25.00–32.00)	30.00 (26.00–34.00)	0.319
Gravida	2.00 (1.00–3.00)	2.00 (1.00–3.00)	0.693
Parity	1.00 (0.00–2.00)	1.00 (0.00–1.50)	0.476
Gestational age (weeks)	10.00 (8.00–12.00)	12.00 (10.00–14.00)	< 0.001
Consanguineous marriage, n (%)	13 (8.2)	5 (5.0)	0.328**
Hb (g/dl)	12.90 (12.00–13.70)	12.65 (11.95–13.30)	0.063
NEU %	73.50 (66.60–79.20)	70.00 (65.55–74.20)	0.002
LYM %	18.80 (13.70–24.40)	22.15 (17.00–25.85)	0.001
PLT (× 103/μl)	255.00 (216.00–304.00)	242.00 (215.00–291.50)	0.172
PCT	0.27 (0.22–0.31)	0.25 (0.22–0.28)	0.032
PDW	12.40 (10.90–14.50)	11.75 (10.35–13.00)	0.003
MPV	10.50 (9.70–11.30)	10.00 (9.70–11.00)	0.161
RDW	13.30 (12.70–14.40)	13.35 (12.90–14.60)	0.129
Ketonuria, n (%)	105 (66.0)	0 (0)	< 0.001**
Monocyte count (103/μl)	0.59 (0.49–0.77)	0.56 (0.50–0.70)	0.352
Eozinofil	0.05 (0.02–0.10)	0.09 (0.05–0.15)	< 0.001
Bazofil	0.03 (0.02–0.05)	0.03 (0.02–0.04)	0.891
Lymphocyte count (103/μl)	1.87 (1.46–2.24)	2.00 (1.70–2.40)	0.084
Neutrophil count (103/μl)	7.25 (5.48–8.68)	6.60 (5.31–7.79)	0.033
ß-HCG (mIU/ml)	80,556.00 (18,981.00–150647.40)	–	–
NLR	3.83 (2.66–5.81)	3.15 (2.59–4.23)	0.004
PLR	142.16 (108.45–190.00)	128.16 (103.49–148.51)	0.003
SII	1027.55 (690.96–1519.00)	808.88 (601.54–1054.89)	< 0.001
PIV	633.74 (394.53–1020.71)	466.98 (320.21–703.03)	< 0.001

HG hyperemesis gravidarum, Hb hemoglobin, NEU neutrophil count, LYM lymphocyte count, PLT platelet count, PCT plateletcrit, PDW platelet distribution width, MPV mean platelet volume, RDW red cell distribution width, HCG human chorionic gonadotropin, NLR neutrophil-to-lymphocyte ratio, PLR platelet-to-lymphocyte ratio, PIV pan-immune-inflammation score, SII systemic immune-inflammation index

*p values in bold are statistically significant