TABLE 2.
Antimicrobial and phenotype | No. of isolates for which the MIC (μg/ml) was as follows:
|
||||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
≤0.004 | 0.008 | ≤0.015 | 0.03 | 0.06 | ≤0.12 | 0.25 | 0.5 | 1 | 2 | 4 | 8 | 16 | 32 | >32 | |
Faropenemb | |||||||||||||||
All | 1,655 | 1,247 | 172 | 173 | 168 | 358 | 592 | 209 | 148 | 3 | |||||
Penicillin susceptible | 1,646 | 1,234 | 138 | 42 | 12 | 6 | |||||||||
Penicillin intermediate | 8 | 13 | 34 | 131 | 155 | 333 | 408 | 63 | 9 | ||||||
Penicillin resistant | 1 | 0 | 0 | 0 | 1 | 19 | 184 | 146 | 139 | 3 | |||||
Amoxicillin-clavulanate | |||||||||||||||
All | 2,503 | 445 | 171 | 125 | 148 | 305 | 572 | 224d | 184e | 46ff | 2 | ||||
Penicillin susceptible | 2,490 | 427 | 113 | 36 | 7 | 4 | 1 | ||||||||
Penicillin intermediate | 13 | 18 | 58 | 89 | 141 | 299 | 423 | 93 | 20 | ||||||
Penicillin resistant | 2 | 148 | 131 | 164 | 46 | 2 | |||||||||
Cefuroxime | |||||||||||||||
All | 3,017 | 217 | 116 | 122d | 226e | 716f | 217 | 68 | 25 | 1 | |||||
Penicillin susceptible | 2,942 | 100 | 29 | 7 | |||||||||||
Penicillin intermediate | 75 | 117 | 87 | 115 | 220 | 486 | 50 | 3 | 1 | ||||||
Penicillin resistant | 6 | 230 | 167 | 65 | 24 | 1 | |||||||||
Imipenem | |||||||||||||||
All | 3,129 | 204 | 201 | 495d | 454e | 231e | 11f | ||||||||
Penicillin susceptible | 3,026 | 44 | 6 | 0 | 2 | ||||||||||
Penicillin intermediate | 103 | 160 | 194 | 450 | 219 | 28 | |||||||||
Penicillin resistant | 1 | 45 | 233 | 20 | 11 | ||||||||||
Ceftriaxone | |||||||||||||||
All | 2,688 | 323 | 200 | 221 | 344 | 518d | 295e | 76f | 53 | 7 | |||||
Penicillin susceptible | 2,662 | 264 | 96 | 49 | 6 | 1 | |||||||||
Penicillin intermediate | 26 | 59 | 104 | 172 | 332 | 377 | 72 | 8 | 4 | ||||||
Penicillin resistant | 6 | 140 | 223 | 68 | 49 | 7 |
Of the 4,725 isolates of S. pneumoniae, 3,078 were penicillin susceptible, 1,154 were penicillin intermediate, and 493 were penicillin resistant.
NCCLS breakpoints are not available for faropenem.
Boldface numbers represent the points at which the MIC90 was achieved.
NCCLS MIC interpretive breakpoint for susceptibility.
NCCLS MIC interpretive breakpoint for intermediate.
NCCLS MIC interpretive breakpoint for resistance.