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Computer simulation of a 500-mg oral dose. Multidose pharmacokinetic data were modeled using the programs in the ADAPT II software package. The points are the computer-simulated weighted means for the patient population. The AUC24 for the 500-mg dose was determined to be 10.08 mg · h/liter. (A) Simulated profile for 500 mg administered once daily. (B) Simulated profile for 250 mg administered q12h.
