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Quinolone-mediated DNA cleavage by S. pneumoniae topoisomerase IV (A) and by its mutant ParC S79F complex (B). Plasmid pBR322 (0.4 μg) was incubated with ParE (1.7 μg) and either wild-type ParC (A) or ParC S79F (B) (0.45 μg). Samples were processed and analyzed as described in the Fig. 1 legend. The abbreviations and lane contents are as described in the Fig. 1 legend.
