Official websites use .gov
A
.gov website belongs to an official
government organization in the United States.
Secure .gov websites use HTTPS
A lock (
) or https:// means you've safely
connected to the .gov website. Share sensitive
information only on official, secure websites.
Inhibitory activities of fluoroquinolones against S. pneumoniae DNA gyrase and topoisomerase IV
| Quinolone | IC50 (μM)
|
|
|---|---|---|
| Gyrasea | Topoisomerase IVb | |
| Gemifloxacin | 5-10 | 2.5-5 |
| Moxifloxacin | 20 | 10 |
| Gatifloxacin | 20-40 | 10-20 |
| Levofloxacin | 80 | 40 |
| Ciprofloxacin | 40 | 20 |
Effects on ATP-dependent supercoiling of relaxed pBR322 DNA.
Measured for decatenation of kinetoplast DNA.
