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Potencies of gemifloxacin and comparator quinolones in stabilizing the cleavable complex with gyrase and topoisomerase IV
| Quinolone | CC25 (μM) for DNA breakage
|
||||
|---|---|---|---|---|---|
| Gyrase
|
Topoisomerase IV
|
||||
| Wild type | GyrA Phe-81 mutation | Wild type | ParC Phe-79 mutation | ||
| Gemifloxacin | 2.5 | 160 | 0.1-0.3 | 10-20 | |
| Moxifloxacin | 10 | 160-320 | 2.5-5 | 160 | |
| Gatifloxacin | 10-20 | 160-320 | 5-10 | 80-160 | |
| Levofloxacin | 20-40 | >640 | 5-10 | >320 | |
| Ciprofloxacin | 40 | >640 | 2.5-5 | >160 | |
