TABLE 4.
MIC distribution by mechanism of resistance in S. pyogenes
| Drug resistance genea | MIC (μg/ml)
|
||
|---|---|---|---|
| Range | 50% | 90% | |
| Telithromycin | |||
| erm(B)C (n =12) | 0.125->64 | 16 | >64 |
| erm(B)I (n = 6) | 0.125-4 | 2 | |
| erm(A)C (n = 3) | 0.03-0.125 | 0.06 | |
| erm(A)I (n = 72) | 0.004-0.125 | 0.06 | 0.06 |
| mef(A) (n = 29) | 0.25-0.5 | 0.5 | 0.5 |
| Others (n = 2) | 0.125 | 0.125 | |
| Total (n = 124) | 0.004->64 | 0.06 | 16 |
| Azithromycin | |||
| erm(B)C (n = 12) | >64 | >64 | >64 |
| erm(B)I (n = 6) | >64 | >64 | |
| erm(A)C (n = 3) | 4->64 | >64 | |
| erm(A)I (n = 72) | 4->64 | 16 | 64 |
| mef(A) (n = 29) | 4-16 | 8 | 8 |
| Others (n = 2) | 2-8 | 8 | |
| Total (n = 124) | 2->64 | 16 | >64 |
| Erythromycin | |||
| erm(B)C (n = 12) | 64->64 | >64 | >64 |
| erm(B)I (n = 6) | >64 | >64 | |
| erm(A)C (n = 3) | 2->64 | 64 | |
| erm(A)I (n = 72) | 1->64 | 4 | 8 |
| mef(A) (n = 29) | 4-16 | 8 | 16 |
| Others (n = 2) | 0.125-0.5 | 0.5 | |
| Total (n = 124) | 0.125->64 | 4 | >64 |
| Clarithromycin | |||
| erm(B)C (n = 12) | 16->64 | >64 | >64 |
| erm(B)I (n = 6) | >64 | >64 | |
| erm(A)C (n = 3) | 0.5-32 | 16 | |
| erm(A)I (n = 72) | 1->64 | 2 | 4 |
| mef(A) (n = 29) | 2-8 | 4 | 8 |
| Others (n = 2) | 0.125-0.25 | 0.25 | |
| Total (n = 124) | 0.125->64 | 2 | >64 |
| Clindamycin | |||
| erm(B)C (n = 12) | 8->64 | >64 | >64 |
| erm(B)I (n = 6) | 0.125-0.25 | 0.25 | |
| erm(A)C (n = 3) | 2->64 | >64 | |
| erm(A)I (n = 72) | 0.06-1 | 0.25 | 0.5 |
| mef(A) (n = 29) | 0.06-0.25 | 0.125 | 0.125 |
| Others (n = 2) | 0.06-2 | 2 | |
| Total (n = 124) | 0.06->64 | 0.125 | >64 |
a
I, inducible; C, constitutive.