TABLE 2.
Demographic and clinical response parameters for Vietnamese adults with uncomplicated falciparum malaria orally treated with artemisinin by a standard- or escalating-dose regimen
| Parameter | Standard dosing | Escalating-dose dosing | P value |
|---|---|---|---|
| Demographics | |||
| Gender (no. of males, no. of females) | 28, 12 | 25, 12 | >0.99 |
| Age (yr)a | 27.7 ± 10.2 | 28.1 ± 10.5 | 0.90 |
| Body wt (kg)a | 49.8 ± 6.1 | 48.8 ± 6.2 | 0.90 |
| Initial parasitemia (no. of parasites/μl of blood) | |||
| Geometric mean | 8,290 | 5,408 | 0.90 |
| Range | 1,120-137,920 | 1,012-208,320 | |
| Clinical response | |||
| PCT50 (h)b | 10.8 ± 3.3 (9.7, 11.9) | 11.2 ± 5.2 (9.5, 13.9) | 0.85 |
| PCT (h)b | 34.1 ± 14.1 (29.6, 38.6) | 50.2c ± 23.4 (42.3, 58.0) | <0.01 |
| PMRT (h)b | 7.3 ± 2.7 (6.5, 8.2) | 11.1 ± 7.0 (8.8, 13.4) | <0.01 |
| PAUC (no. of parasites · h/μl of blood)d | 271,522 ± 353,430 (138,971) | 536,359c ± 1,724,730 (100,386) | 0.09 |
| FST (h)b | 24.8 ± 9.6 (21.7, 27.9) | 25.7 ± 15.9 (20.4, 31.0) | 0.60 |
a
Values are means ± standard deviations.
b
Values are means ± standard deviations (95% confidence intervals).
c
Including the arbitrary value of 120 h for one patient.
d
Values are means ± standard deviations (geometric means).