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. 2002 Apr;46(4):977–981. doi: 10.1128/AAC.46.4.977-981.2002

TABLE 1.

Anti-influenza virus activities of T-705, GS 4071, amantadine, and ribavirin

Virus type and strain IC50 (μg/ml)a
T-705 GS 4071 Amantadine Ribavirin
A (H1N1)
    PR/8/34 0.16 0.0039 >50 7.7
    FM/1/47 0.20 0.0056 0.30 1.6
    NWS/33 0.091 0.0020 >50 12
    Yamagata/120/86 0.12 0.0096 1.6 4.1
    Suita/1/89 0.029 0.0025 >50 8.7
A (H2N2)
    Kaizuka/2/65 0.029 0.68 0.15 8.3
    Okuda/57 0.013 0.00044 0.25 4.9
    Japan/305/57 0.30 0.00039 0.062 13.8
    Takathuki/4/65 0.048 0.00017 0.19 Not tested
A (H3N2)
    Port Chalmers/1/73 0.46 0.00060 Not tested 5.8
    Aichi/2/68 0.078 0.0030 0.63 4.3
    Ibaraki/1/90 0.30 0.00049 0.47 4.8
    Kitakyushu/159/93 0.48 0.00056 >50 20
B
    Nagasaki/1/87 0.089 0.0063 >50 19
    Guandong/5/94 0.053 0.031 >50 1.2
    Mie/1/93 0.039 0.015 >50 4.6
C
    Taylor/1233/47 0.044 >100 Not tested Not tested
    Yamagata/3/96 0.057 >100 Not tested Not tested
    JJ/50 0.030 >100 Not tested Not tested
GS 4071-resistant virus A/PR/8/34b 0.095c 25c Not tested Not tested
a

The Values are averages of results from two or three independent experiments.

b

Isolated by passage in GS 4071 six times.

c

The values are IC90s (the concentrations required to reduce the viral yield by 1 log10).