TABLE 1.
Anti-influenza virus activities of T-705, GS 4071, amantadine, and ribavirin
Virus type and strain | IC50 (μg/ml)a
|
|||
---|---|---|---|---|
T-705 | GS 4071 | Amantadine | Ribavirin | |
A (H1N1) | ||||
PR/8/34 | 0.16 | 0.0039 | >50 | 7.7 |
FM/1/47 | 0.20 | 0.0056 | 0.30 | 1.6 |
NWS/33 | 0.091 | 0.0020 | >50 | 12 |
Yamagata/120/86 | 0.12 | 0.0096 | 1.6 | 4.1 |
Suita/1/89 | 0.029 | 0.0025 | >50 | 8.7 |
A (H2N2) | ||||
Kaizuka/2/65 | 0.029 | 0.68 | 0.15 | 8.3 |
Okuda/57 | 0.013 | 0.00044 | 0.25 | 4.9 |
Japan/305/57 | 0.30 | 0.00039 | 0.062 | 13.8 |
Takathuki/4/65 | 0.048 | 0.00017 | 0.19 | Not tested |
A (H3N2) | ||||
Port Chalmers/1/73 | 0.46 | 0.00060 | Not tested | 5.8 |
Aichi/2/68 | 0.078 | 0.0030 | 0.63 | 4.3 |
Ibaraki/1/90 | 0.30 | 0.00049 | 0.47 | 4.8 |
Kitakyushu/159/93 | 0.48 | 0.00056 | >50 | 20 |
B | ||||
Nagasaki/1/87 | 0.089 | 0.0063 | >50 | 19 |
Guandong/5/94 | 0.053 | 0.031 | >50 | 1.2 |
Mie/1/93 | 0.039 | 0.015 | >50 | 4.6 |
C | ||||
Taylor/1233/47 | 0.044 | >100 | Not tested | Not tested |
Yamagata/3/96 | 0.057 | >100 | Not tested | Not tested |
JJ/50 | 0.030 | >100 | Not tested | Not tested |
GS 4071-resistant virus A/PR/8/34b | 0.095c | 25c | Not tested | Not tested |
The Values are averages of results from two or three independent experiments.
Isolated by passage in GS 4071 six times.
The values are IC90s (the concentrations required to reduce the viral yield by 1 log10).