TABLE 1.
Anti-influenza virus activities of T-705, GS 4071, amantadine, and ribavirin
| Virus type and strain | IC50 (μg/ml)a
|
|||
|---|---|---|---|---|
| T-705 | GS 4071 | Amantadine | Ribavirin | |
| A (H1N1) | ||||
| PR/8/34 | 0.16 | 0.0039 | >50 | 7.7 |
| FM/1/47 | 0.20 | 0.0056 | 0.30 | 1.6 |
| NWS/33 | 0.091 | 0.0020 | >50 | 12 |
| Yamagata/120/86 | 0.12 | 0.0096 | 1.6 | 4.1 |
| Suita/1/89 | 0.029 | 0.0025 | >50 | 8.7 |
| A (H2N2) | ||||
| Kaizuka/2/65 | 0.029 | 0.68 | 0.15 | 8.3 |
| Okuda/57 | 0.013 | 0.00044 | 0.25 | 4.9 |
| Japan/305/57 | 0.30 | 0.00039 | 0.062 | 13.8 |
| Takathuki/4/65 | 0.048 | 0.00017 | 0.19 | Not tested |
| A (H3N2) | ||||
| Port Chalmers/1/73 | 0.46 | 0.00060 | Not tested | 5.8 |
| Aichi/2/68 | 0.078 | 0.0030 | 0.63 | 4.3 |
| Ibaraki/1/90 | 0.30 | 0.00049 | 0.47 | 4.8 |
| Kitakyushu/159/93 | 0.48 | 0.00056 | >50 | 20 |
| B | ||||
| Nagasaki/1/87 | 0.089 | 0.0063 | >50 | 19 |
| Guandong/5/94 | 0.053 | 0.031 | >50 | 1.2 |
| Mie/1/93 | 0.039 | 0.015 | >50 | 4.6 |
| C | ||||
| Taylor/1233/47 | 0.044 | >100 | Not tested | Not tested |
| Yamagata/3/96 | 0.057 | >100 | Not tested | Not tested |
| JJ/50 | 0.030 | >100 | Not tested | Not tested |
| GS 4071-resistant virus A/PR/8/34b | 0.095c | 25c | Not tested | Not tested |
a
The Values are averages of results from two or three independent experiments.
b
Isolated by passage in GS 4071 six times.
c
The values are IC90s (the concentrations required to reduce the viral yield by 1 log10).