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. 2005 Oct 27;33(18):6034–6047. doi: 10.1093/nar/gki904

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© The Author 2005. Published by Oxford University Press. All rights reserved

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Influence of pH on DEPC reactivity toward a 176 bp DNA fragment incubated in the presence of C-1305 (A) Experiments were carried out in 10 mM Tris–HCl/NaCl buffer with increasing pH value (ranging from 5.55 to 9.0). Control tracks with DNA (D) were added for each pH value and contained no drug. G, guanine track; C, DNA unmodified; D, control DNA. 1, 20–1 and 20 µM C-1305. Optical density analysis of specific drug–DNA interaction sites. (B) Arrow indicates the position of the band on which the cleavage intensity for each compound was measured by densitometry. The graph represents an increase of the cleavage at guanine site over control/untreated DNA.