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. 2005 Oct 27;33(18):6034–6047. doi: 10.1093/nar/gki904

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© The Author 2005. Published by Oxford University Press. All rights reserved

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Effect of triazolo- and imidazoacridone derivatives on DEPC reactivity toward a 176 bp DNA fragment (A) Optical density analysis of specific drug–DNA interaction sites. (B) Arrow indicates the position of the band on which the cleavage intensity for each compound was measured by densitometry. The graph represents an increase of the cleavage at guanine sites compared to control/untreated DNA.