Table 2.

Univariate and multivariate risk factor analysis of EM after hepatectomy in patients with HCC

	Univariate		Multivariate
	All		Preoperative		Postoperative
Variable	HR (95% CI)	P value	HR (95% CI)	P value	HR (95% CI)	P value
Sex, Female vs Male	0.941(0.386,2.296)	.894
Age, ≥ 60 vs < 60	0.426(0.198,0.918)	.029	0.639(0.265,1.540)	.319	0.637(0.243,1.670)	.359
Charlson Comorbidity Index	1.034(0.833,1.284)	.762
ASA classification	1.064(0.567,1.995)	.847
Abdominal Surgery History, Yes vs No	1.682(0.558,5.065)	.355
HBV Infection, Yes vs No	0.619(0.205,1.867)	.394
Child–Pugh g rade, B vs A	3.444(1.247,9.511)	.017	7.892(2.318,26.865)	<.001	5.419(1.422,20.651)	.013
BCLC staging	2.736(1.796,4.166)	<.001	1.955(1.172,3.261)	.010	1.660(0.948,2.906)	.076
Tumor burden score	1.294(1.179,1.419)	<.001	1.256(1.127,1.400)	<.001	1.174(1.034,1.333)	.014
AFP, > 400 μg/L vs ≤ 400 μg/L	3.129(1.565,6.254)	.001	1.233(0.525,2.897)	.631	0.884(0.353,2.213)	.792
NLR	1.163(0.948,1.426)	.148
Anatomical hepatectomy, Yes vs No	2.784(1.113,6.962)	.029			0.943(0.266,3.348)	.928
Resection extent, Major vs minor	6.600(2.894,15.053)	<.001			1.894(0.621,5.773)	.262
Operation duration (min)	1.004(1.002,1.005)	<.001			1.002(0.999,1.005)	.169
Operation blood loss (ml)	1.000(1.000,1.001)	.032			1.000(0.999,1.000)	.301
Textbook Outcome, No vs Yes	6.810(3.139,14.773)	<.001			5.124(1.924,13.643)	.001
Microvascular Invasion, Yes vs No	5.922(2.738,12.812)	<.001			2.858(1.050,7.785)	.040
Degree of Inflammation and Necrosis(G), 2/3/4 vs 0/1	1.422(0.616,3.284)	.409
Degree of Fibrosis(S), 2/3/4 vs 0/1	1.457(0.605,3.510)	.401
Postoperative hospital stays	1.050(1.015,1.086)	.005			0.981(0.937,1.028)	.423

ASA classification, American Society of Anesthesiologists Physical Status Classification; HBV infection, Hepatitis B Virus infection; BCLC staging, Barcelona Clinic Liver Cancer staging system; NLR, Neutrophil-to-Lymphocyte Ratio