TABLE 1.
Treatmenta | No. of rabbits | No. of rabbits with sterile bone | Mean ± SD bacterial count (log10 CFU/g of bone) |
---|---|---|---|
None | 9 | 0 | 6.3 ± 0.6 |
Q-D | 12 | 1 | 4.7 ± 1.3b |
Vancomycin | 10 | 0 | 5.1 ± 0.8 |
Q-D + rifampin | 10 | 10 | 1.8 ± 0.1b, c |
Vancomycin + rifampin | 11 | 5 | 2.9 ± 1.5b, c |
Rabbits were treated i.m. for 7 days with either Q-D (30 mg/kg every 8 h) or vancomycin (60 mg/kg b.i.d.) alone or in combination with rifampin (10 mg/kg b.i.d.).
Significantly different from untreated controls (P < 0.01).
Significantly different from vancomycin and Q-D monotherapy groups (P < 0.01).