TABLE 1.

Effect of antibiotic treatment on experimental methicillin-resistant S. aureus prosthetic knee infection in rabbits

Treatmenta	No. of rabbits	No. of rabbits with sterile bone	Mean ± SD bacterial count (log10 CFU/g of bone)
None	9	0	6.3 ± 0.6
Q-D	12	1	4.7 ± 1.3b
Vancomycin	10	0	5.1 ± 0.8
Q-D + rifampin	10	10	1.8 ± 0.1b, c
Vancomycin + rifampin	11	5	2.9 ± 1.5b, c

^aRabbits were treated i.m. for 7 days with either Q-D (30 mg/kg every 8 h) or vancomycin (60 mg/kg b.i.d.) alone or in combination with rifampin (10 mg/kg b.i.d.).

^bSignificantly different from untreated controls (P < 0.01).

^cSignificantly different from vancomycin and Q-D monotherapy groups (P < 0.01).