FIG. 2.

Effect of oral administration of compounds on nasal virus titers, nasal inflammatory cell counts, and fever of ferrets infected with influenza virus A (H3N2) virus. Nasal virus titers (A), total numbers of inflammatory cells in nasal washes (B), and changes in temperature relative to baseline temperatures (C) were monitored in ferrets at the indicated times after infection. Ferrets were left untreated (▪) or were treated twice daily with oral 5-mg/kg doses of GS4104 (⧫) or BCX-1827 (▴) for 3 days beginning 2 h prior to infection with influenza virus clone 7a. Values are means ± standard errors of the means (error bars) for three to four animals.