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Measurement of polymerization velocity of wt and YMDD-mutant polymerases, using probes specific for early and late HBV genomic replication
| HBV polymerasea | (−) strand probe 8F (107 molecules) | (+) strand probe 4RA (106 molecules) | % of polymerase HBV particles hybridizing to (+) strand probe 4RA | % Replication relative to wt polymerase |
|---|---|---|---|---|
| wt | 5.5 | 9.9 | 18 | 100 |
| LMMV | 5.6 | 4.9 | 9 | 50 |
| MI | 5.5 | 3.4 | 6 | 33 |
| LMMI | 4.9 | 4.6 | 10 | 55 |
Abbreviations: LMMV, L528M M552V; MI, M552I; LMMI, L528M M552I.
