TABLE 2.

Mean K_m values for each dNTP determined by using wt and YMDD-mutant HBV polymerases^a

HBV polymerase	Mean dNTP Km values (μM) ± SEM
	dCTP	dATP	dGTP	TTP
wt	0.09 ± 0.01	0.18 ± 0.02	0.07 ± 0.01	0.08 ± 0.01
LMMV	0.16 ± 0.03	0.53 ± 0.1	0.16 ± 0.04	0.23 ± 0.06
MI	0.30 ± 0.06	0.79 ± 0.18	0.35 ± 0.10	0.42 ± 0.08
LMMI	0.24 ± 0.09	0.74 ± 0.07	0.18 ± 0.03	0.22 ± 0.02
LM	0.12 ± 0.01	0.40 ± 0.03	0.11 ± 0.03	0.19 ± 0.01
MV	0.32 ± 0.08	1.15 ± 0.18	0.29 ± 0.09	0.38 ± 0.06

^aMean values are based on determinations from four to six core particle assays from transfected or transduced cells; abbreviations: LMMV, L528M M552V; MI, M552I; LMMI, L528M M552I; LM, L528M; MV, M552V.