TABLE 6.

Enzymatic activities of YMDD-mutant polymerases relative to wt polymerase, calculated at low substrate concentrations

HBV polymerasea	% Enzyme activity relative to wt polymerase
	dATP	dGTP	dCTP	TTP
wt	100	100	100	100
LMMV	46	53	71	42
MI	23	17	35	19
LMMI	40	64	63	62
LM	82	79	83	75
MV	25	24	34	25

^aAbbreviations: LMMV, L528M M552V; MI, M552I; LMMI, L528M M552I; LM, L528M; MV, M552V