TABLE 5.
Duration from cessation of treatment to 1% parasitemia and growth periods from 0.01 to 1% parasitemia in a series of six successive recrudescencesa
Recrudescence | Duration (days) | Growth period (days) |
---|---|---|
First | 11.6 ± 0.6 | 4.3 ± 0.6 |
Second | 12.0 ± 0.0 | 4.7 ± 0.6 |
Third | 11.3 ± 1.5 | 4.3 ± 0.6 |
Fourth | 11.0 ± 1.0 | 4.3 ± 0.6 |
Fifth | 12.3 ± 1.5 | 4.7 ± 0.6 |
Sixth | 12.7 ± 1.2 | 4.3 ± 0.6 |
The recrudescence experiment was repeated successively six times by using cloned parasites. Each recrudescence experiment was carried out in triplicate, and the recrudescent parasites in three flasks were mixed and subjected to the following recrudescence experiment. A series of recrudescence experiments was conducted three times. The mean± standard deviation duration and growth period in a representative series are shown with SD. The difference in the mean duration was not statistically significant (P = 0.476). The difference in the mean growth period was not statistically significant (P = 0.923).