TABLE 1.

Evolution of primary and secondary PI mutations during salvage therapy in 78 patients presenting with a single PI resistance mutation

Amino acid no. of presenting mutation(s)		Previous therapy		Salvage therapy		Amino acid no. of follow-up mutation(s)
Primary	Secondary	Protease inhibitor(s)	Duration (wk)	Protease inhibitor(s)	Duration (wk)	Primary	Secondary
30	36	NFV	12	RTV-SQV	44	30, 90	20, 36, 54, 71, 88
30	36	SQV, IDV, NFV	51	RTV-SQV	19	30	36
30	36	SQV, NFV	107	IDV	78		36, 46, 71, 88
30	20, 36	SQV, NFV	53	RTV-SQV	8	84, 90	20, 36, 71
30	20, 36	NFV	20	RTV-SQV	9	84, 90	20, 36, 71, 73
30	71	IDV, NFV	27	RTV-SQV	6	90	20, 32, 36, 71, 73
30	36	IDV, NFV	68	RTV-SQV	71	30, 84, 90	36, 88
30	10	SQV, IDV, NFV	113	RTV-SQV	38	30	71, 88
30	71, 88	NFV	57	IDV	76	30, 90	20, 46, 71, 88
30	10, 20, 71, 88	NFV	49	RTV-SQV	41	30, 90	10, 20, 46, 53, 54, 71, 88
30	36, 71, 88	IDV, NFV	88	APV	50	30	36, 46, 71, 88
30	36	RTV, NFV	108	IDV	85	82	36, 46, 71, 88
30		NFV	73	RTV-SQV, IDV	35		46, 73
30	10, 88	IDV, RTV, NFV	157	RTV-SQV, RTV-APV, RTV-IDV	41	90	10, 54, 88
30	88	SQV, NFV	52	SQV	40	90	36
30	10, 36	NFV	16	RTV-SQV	44	30, 90	20, 36, 54, 88
48		SQV	24	IDV	24	48, 82	10, 71
48	71	SQV	24	IDV	24	48, 82	10, 54, 71
48	71	SQV	26	IDV, RTV-SQV	46	48, 82	10, 54, 71
48	10, 36, 54	SQV	40	NFV, RTV-IDV	100	48, 82	10, 36, 54
48	10	SQV	24	IDV	24	48, 82	10
82	10, 46, 54, 88	SQV, IDV	59	RTV-SQV	18	90	10, 20, 71, 73
82	10, 46, 71, 88	IDV	84	NFV-SQV, RTV-SQV	120	84, 90	10, 46, 71, 88
82	10, 46, 71	IDV	53	RTV-SQV	43	82, 90	10, 32, 46, 53, 71
82	10, 24, 32, 46, 71, 73	IDV	68	RTV-SQV	75	84	10, 24, 46, 73
82	71	SQV, IDV	78	RTV-SQV	21	82	71
82	10, 36, 54, 73	IDV	44	RTV-SQV	76	48, 82	10, 20, 36, 54, 73
82	32, 46, 47	IDV	93	SQV, NFV-SQV	46	82, 90	10, 46, 54, 71
82		IDV	68	NFV-SQV, NFV	61	90
82	54	RTV	30	NFV	71	82, 90	10, 54, 71
82	10, 20, 24, 36, 71, 73	IDV, NFV-SQV	89	APV	49	82	10, 20, 24, 36, 46, 54, 71, 73
82	10, 54	IDV, NFV	20	RTV-SQV	22	48, 82, 84	10, 53, 54, 71
82	32, 36, 46, 71	IDV	59	RTV-SQV	90	82	10, 24, 36, 54, 71
82	10, 24, 46	IDV, SQV, NFV	136	APV	56	82	10, 24, 46
82	10, 24, 46	SQV, IDV	52	NFV	43	82	10, 24, 46
82	10, 24, 46	NFV, IDV	83	NFV, NFV-SQV	26	82, 84	10, 24, 46
82	46	IDV	124	NFV	44	82	10, 46
82	46	IDV	96	APV	24	82	46
82	20, 46, 71	IDV	54	NFV	16	82	20, 46, 71
82	10, 20, 24, 36, 46	IDV	9	RTV-SQV	44	82	10, 20, 24, 36, 46, 54
82	10, 46, 53, 54, 71	IDV	58	RTV-SQV	16	82, 90	10, 53, 54, 71
82	10, 36, 54	NFV	123	RTV-SQV	15	48, 82, 90	10, 36, 46, 54
84	10, 36, 71	IDV, NFV	68	RTV-SQV	35	84	10, 36, 71
84	46, 71	IDV	57	RTV-SQV	81	48, 84	10, 46, 71
84	10, 46, 54, 71	IDV, SQV	65	APV	13	84	10, 46, 54, 71
90	10, 36	SQV	52	IDV	11	90	10, 20, 36, 71
90	10, 54	IDV	43	RTV-SQV	28	84, 90	10, 46, 73
90	10, 46, 53, 71, 73	SQV, IDV, NFV	116	RTV-SQV, IDV	36	90	10, 53, 71, 73
90	71, 73	SQV	48	RTV-SQV	149	84, 90	10, 71, 73
90	71	IDV	48	RTV-SQV	41	90	71
90	10, 53, 71, 73	SQV	40	NFV, IDV, RTV-SQV	69	90	10, 24, 46, 53, 71, 73
90	71	SQV, NFV	104	IDV	124	90	46, 73
90		IDV	67	RTV-SQV	17	84, 90	73
90	10, 20, 36, 73	SQV, IDV, RTV-SQV, NFV-SQV	135	IDV	28	90	10, 20, 36, 73
90	20, 71, 73	IDV	98	RTV-SQV	29	90	20, 71, 73
90	71, 88	SQV, NFV	73	RTV-SQV	14	90	10, 71, 88
90	10, 20, 71	SQV, NFV	55	IDV	37	90	10, 71, 73
90	10, 46, 73	IDV	66	NFV	59	90	10, 73
90	10, 71, 73	SQV, IDV, NFV	94	RTV-IDV, RTV-APV-SQV	71	84, 90	10, 54, 71, 73
90	20, 36, 71	IDV, NFV	79	RTV-SQV	65	90	20, 36, 54, 71/PICK>{tt}
90	20, 46, 73	NFV	56	RTV-IDV	72	90	20, 73
90	10, 46, 73	IDV, NFV	112	RTV-SQV	35	90	10, 73
90	46, 71, 73	IDV	6	NFV, IDV-SQV, RTV-SQV, APV-NFV	154	84, 90	10, 54, 71, 73
90		SQV, SQV-APV	36	NFV, RTV, RTV-IDV	169	84, 90	10, 20, 36, 71
90	10, 46, 73	IDV, NFV-SQV	108	NFV-SQV, RTV-SQV	76	90	10, 46, 73
90	10, 54, 71, 73	IDV, IDV-SQV, NFV-SQV	124	NFV, RTV-APV	118	90	10, 36, 71, 73
90	10, 20, 36, 46, 73	NFV	68	RTV-SQV	28	84, 90	10, 20, 36, 46, 73
90	71, 73	IDV, NFV, SQV	83	RTV-APV, LPV	75	84, 90	10, 54, 71, 73
90	10, 46	IDV, NFV-SQV, SQV	125	APV	47	90	10
90	46, 71	NFV	137	APV	46	90	10, 71
90	32, 46, 47	IDV	58	NFV, SQV, RTV-NFV	83	90	10
90	10, 71, 73	SQV	35	NFV	17	90	10, 71, 73
90	20, 46	IDV, SQV	136	APV	35	90	10, 20
90	10, 46, 73	IDV, NFV-SQV, IDV	89	APV	33	90	73
90	20, 36	NFV	72	APV	51	90	10, 73
90	46	NFV, NFV-SQV	96	APV, RTV-SQV	62	90
90	10, 46, 53, 73	SQV, IDV, RTV-SQV, NFV	164	RTV-IDV	20	84, 90	10, 53, 73
90	10, 20, 36, 46, 71	IDV	106	APV	37	90	10, 20, 36, 71