TABLE 2.
BMS-284756 MICs for S. aureus and associated QRDR amino acid substitutions in topoisomerase IV and DNA gyrase
| MIC (μg/ml)
|
No. of isolates | Amino acid substitutiona
|
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| GrlA
|
GyrA
|
GrlB
|
|||||||||
| BMSr 284756 | Ciprofloxacin | S80 | E84 | P144 | S84 | S85 | E88 | E422 | E471 | H478 | |
| 64 | 64 | 1 | F | K | L | P | |||||
| 8 | 256 | 1 | Y | G | L | ||||||
| 4 | 32-256 | 3 | F | L | D | ||||||
| 2 | 128 | 1 | F | L | D | ||||||
| 2 | 16 | 1 | K | L | D | ||||||
| 2 | 16 | 1 | F | L | |||||||
| 1 | 128 | 1 | F | L | K | ||||||
| 0.5 | 16 | 1 | F | S | K | D | |||||
| 0.5 | 8 | 1 | F | K | |||||||
| 0.25 | 8 | 1 | F | G | |||||||
| 0.06 | 0.12 | 1 | Y | ||||||||
| 0.03 | 2 | 1 | G | Y | |||||||
| 0.03 | 1 | 1 | F | S | D | ||||||
| 0.03 | 1 | 1 | F | ||||||||
| 0.03 | 0.25 | 1 | D | ||||||||
| 0.015 | 2 | 1 | Y | D | |||||||
| 0.015 | 1 | 1 | F | S | D | ||||||
| 0.007 | 0.12-0.25 | 2 | S | D | |||||||
a
Y, tyrosine; F, phenylalanine; K, lysine; G, glycine; P, proline; S, serine; D, aspartic acid; E, glutamic acid; L, leucine; H, histidine.