Table 1.
Patient Characteristics Between Subclasses
| Variables | Class 1 (N=269) | Class 2 (N=983) | Class 3 (N=225) | Class 4 (N=597) | Class 5 (N=151) | p value |
|---|---|---|---|---|---|---|
| Age, y | 57 (42–69) | 53 (39–65) | 46 (35–60) | 44 (35–57) | 43 (33–58) | <0.001 |
| Sex (male%) | 175 (65.1) | 649 (66.0) | 137 (60.9) | 360 (60.3) | 90 (59.6) | 0.123 |
| Body mass index, kg/m2 | 24.1 (21.5–26.3) | 25.0 (22.5–27.9) | 25.1 (22.9–27.7) | 25.2 (23.0–28.2) | 24.8 (22.6–27.6) | <0.001 |
|
Time interval from onset to admission, days |
1 (1–2) | 1 (1–2) | 2 (1–2) | 2 (1–2) | 2 (1–3) | <0.001 |
| Comorbidities (%) | ||||||
| Hypertension | 101 (37.5) | 357 (36.3) | 71 (31.6) | 162 (27.1) | 38 (25.2) | <0.001 |
| Diabetes mellitus | 62 (23.0) | 247 (25.1) | 44 (19.6) | 128 (21.4) | 29 (19.2) | 0.194 |
| Chronic kidney diseases | 6 (2.2) | 17 (1.7) | 1 (0.4) | 3 (0.5) | 1 (0.7) | 0.086 |
| Etiologies (%) | ||||||
| Biliary | 142 (52.8) | 465 (47.3) | 96 (42.7) | 236 (39.5) | 61 (40.4) | 0.001 |
| Hypertriglyceridemia | 67 (24.9) | 308 (31.3) | 88 (39.1) | 223 (37.4) | 54 (35.8) | 0.001 |
| Alcoholic | 18 (6.7) | 62 (6.3) | 26 (11.6) | 49 (8.2) | 16 (10.6) | 0.044 |
| Others | 42 (15.6) | 148 (15.1) | 15 (6.7) | 89 (14.9) | 20 (13.2) | 0.018 |
| Laboratory indicators | ||||||
| Platelet count, x109/L | 113 (90–142) | 161 (138–187) | 173 (146–206) | 220 (196–247) | 263 (214–305) | <0.001 |
| WBC, x109/L | 8.9 (6.0–12.3) | 10.1 (7.2–13.6) | 12.3 (8.8–15.6) | 11.2 (8.3–14.1) | 14.0 (10.2–17.8) | <0.001 |
| ALT, IU/L | 32 (16–87) | 29 (17–78) | 28 (17–66) | 24 (16–66) | 26 (15–68) | 0.244 |
| BUN, mmol/L | 5.4 (4.0–8.2) | 4.5 (3.3–6.3) | 5.8 (3.9–7.8) | 3.8 (2.9–4.9) | 3.8 (2.8–5.3) | <0.001 |
| Creatinine, μmol/L | 74 (61–92) | 69 (57–84) | 68 (55–85) | 65 (53–76) | 64 (51–77) | <0.001 |
| CRP, mg/L | 118 (37–234) | 110 (32–193) | 192 (121–282) | 126 (46–203) | 157 (92–226) | <0.001 |
| D-dimers, mg/L | 2.8 (0.8–5.0) | 1.6 (0.7–3.7) | 3.9 (2.3–6.1) | 1.5 (0.8–3.3) | 3.0 (1.3–4.9) | <0.001 |
| Fibrinogen, g/L | 3.7 (2.7–5.5) | 4.1 (3.0–5.6) | 5.1 (3.8–6.4) | 4.8 (3.4–6.2) | 5.3 (4.4–6.2) | <0.001 |
| Tbil, mmol/L | 24.5 (16.0–35.2) | 21.5 (15.4–29.8) | 23.2 (15.8–35.4) | 19.4 (14.5–27.4) | 20.0 (14.4–31.0) | <0.001 |
| Balthazar score | 3 (1–4) | 2 (1–4) | 4 (3–4) | 2 (1–3) | 3 (2–4) | <0.001 |
| Severity (%) | ||||||
| MAP | 136 (50.6) | 640 (65.1) | 48 (21.3) | 396 (66.3) | 64 (42.4) | <0.001 |
| MSAP | 83 (30.9) | 273 (27.8) | 124 (55.1) | 190 (31.8) | 73 (48.3) | <0.001 |
| SAP | 50 (18.6) | 70 (7.1) | 53 (23.6) | 11 (1.8) | 14 (9.3) | <0.001 |
| Outcomes | ||||||
| IPN (%) | 21 (7.8) | 24 (2.4) | 21 (9.3) | 7 (1.2) | 8 (5.3) | <0.001 |
| Surgical intervention (%) | 28 (10.4) | 38 (3.9) | 26 (11.6) | 9 (1.5) | 12 (7.9) | <0.001 |
| In-hospital mortality (%) | 21 (7.8) | 12 (1.2) | 7 (3.1) | 6 (1.0) | 2 (1.3) | <0.001 |
Notes: Continuous data are presented as median (IQR); categorical data are represented as count (percentage). First measured laboratory indicators after admission are shown.
Abbreviations: WBC, white blood cell count; ALT, alanine aminotransferase; BUN, blood urine nitrogen; CRP, C-reactive protein; Tbil, total bilirubin; MAP, mild acute pancreatitis; MASP, moderately severe acute pancreatitis; SAP, severe acute pancreatitis; IPN, infected pancreatic necrosis.