TABLE 3.
Activities of phosphonate nucleotides and alkoxyalkyl analogs against strains of VV
| Compound | EC50 (μM)a
|
||||
|---|---|---|---|---|---|
| Copenhagen | WR | Elstree | IHD | NYC | |
| CDV | 46.2 ± 11.9 | 45.8 ± 16.6 | 41.6 ± 22.4 | 13.4 ± 5.6 | 10.1 ± 1.3 |
| HDP-CDV | 0.8 ± 0.4 | 1.1 ± 1.0 | 1.2 ± 0.8 | 0.2 ± 0.0 | 0.4 ± 0.0 |
| ODE-CDV | 0.2 ± 0.1 | 0.24 ± 0.2 | 0.4 ± 0.1 | 0.1 ± 0.0 | 0.1 ± 0.0 |
| cCDV | 50.6 ± 13.1 | 58.8 ± 10.9 | 41.6 ± 19.5 | 10.9 ± 1.3 | 10.3 ± 1.3 |
| HDP-cCDV | 3.8 ± 1.5 | 5.6 ± 1.3 | 3.8 ± 2.7 | 0.1 ± 0.0 | 0.1 ± 0.0 |
| ODE-cCDV | 1.1 ± 1.0 | 0.58 ± 0.2 | 0.5 ± 0.4 | 0.04 ± 0.02 | 0.03 ± 0 |
a
Values are the means of two assays ± standard deviations.