TABLE 1.

In vitro susceptibilities of 198 isolates of Aspergillus species to amphotericin B, itraconazole, and three investigational triazole antifungal agents

Organism (no. tested) and antifungal agent	MIC (μg/ml)			% Susceptible at MIC (μg/ml) of:
	Range	50%	90%	0.25	0.5	1	2	4
A. fumigatus (114)
Amphotericin B	0.5-4	1	1	0	2	98	99	100
Itraconazole	0.25-2	1	2	2	24	77	100	100
Posaconazole	0.03-1	0.25	0.5	81	99	100	100	100
Ravuconazole	0.25-4	0.5	0.5	16	95	98	99	100
Voriconazole	0.12-4	0.25	0.5	88	98	99	99	100
A. niger (22)
Amphotericin B	0.25-1	1	1	9	46	100	100	100
Itraconazole	0.5-2	2	2	0	9	36	100	100
Posaconazole	0.25-1	0.5	1	41	82	100	100	100
Ravuconazole	0.5-4	1	2	0	14	50	96	100
Voriconazole	0.25-2	0.5	1	14	73	96	100	100
A. flavus (13)
Amphotericin B	1-2	1	2	0	0	62	100	100
Itraconazole	0.25-1	0.5	1	8	69	100	100	100
Posaconazole	0.12-1	0.25	0.5	54	92	100	100	100
Ravuconazole	0.12-1	0.5	1	8	62	100	100	100
Voriconazole	0.06-1	0.5	1	23	92	100	100	100
A. versicolor (9)
Amphotericin B	1-2	1		0	0	89	100	100
Itraconazole	0.5-2	2		0	11	33	100	100
Posaconazole	0.06-2	0.5		33	67	78	100	100
Ravuconazole	0.12-2	1		11	44	89	100	100
Voriconazole	0.25-2	0.5		44	56	89	100	100
A. terreus (8)
Amphotericin B	1-4	2		0	0	25	88	100
Itraconazole	0.25-0.5	0.5		25	100	100	100	100
Posaconazole	0.06-0.25	0.12		100	100	100	100	100
Ravuconazole	0.25-0.5	0.25		50	100	100	100	100
Voriconazole	0.25-0.5	0.25		75	100	100	100	100
Aspergillus spp. (32)
Amphotericin B	0.12-2	1	2	3	3	75	100	100
Itraconazole	0.5->8	1	2	0	25	72	94	97
Posaconazole	0.06->8	0.25	1	63	81	94	94	94
Ravuconazole	0.12->8	0.5	1	31	66	91	94	97
Voriconazole	0.12->8	0.25	1	50	78	94	94	97
All isolates (198)
Amphotericin B	0.12-4	1	2	2	6	89	99	100
Itraconazole	0.25->8	1	2	2	27	72	99	99
Posaconazole	0.03->8	0.25	0.5	70	92	98	99	99
Ravuconazole	0.12->8	0.5	1	17	78	92	99	99
Voriconazole	0.06->8	0.25	0.5	67	90	98	99	99