TABLE 2.

In vitro susceptibilities of 41 isolates of miscellaneous filamentous fungi to amphotericin B, itraconazole, and three investigational triazole antifungal agents

Organism (no. tested) and antifungal agent	MIC (μg/ml)			% Susceptible at MIC (μg/ml) of:
	Range	50%	90%	0.25	0.5	1	2	4
Penicillium spp. (19)
Amphotericin B	0.12-2	1	1	16	42	95	100	100
Itraconazole	0.12-2	0.5	2	16	63	89	100	100
Posaconazole	0.03-1	0.25	1	74	89	100	100	100
Ravuconazole	0.03-1	0.5	1	42	74	100	100	100
Voriconazole	0.06->8	0.5	1	26	74	95	95	95
Fusarium spp. (7)
Amphotericin B	1-2	1		0	0	86	100	100
Itraconazole	0.5->8	>8		0	14	14	14	14
Posaconazole	0.25->8	>8		14	29	29	29	43
Ravuconazole	0.5->8	>8		0	14	29	29	29
Voriconazole	0.5->8	8		0	14	29	29	43
Rhizopus spp. (4)
Amphotericin B	0.5-1	1		0	25	100	100	100
Itraconazole	4->8	4		0	0	0	0	50
Posaconazole	1-4	2		0	0	25	75	100
Ravuconazole	1-8	1		0	0	50	75	75
Voriconazole	>8	>8		0	0	0	0	0
Mucor spp. (2)
Amphotericin B	0.5	0.5		0	100	100	100	100
Itraconazole	>8	>8		0	0	0	0	0
Posaconazole	>8	>8		0	0	0	0	0
Ravuconazole	>8	>8		0	0	0	0	0
Voriconazole	>8	>8		0	0	0	0	0
Paecilomyces spp. (2)
Amphotericin B	0.5	0.5		0	100	100	100	100
Itraconazole	0.25-0.5	0.25		50	100	100	100	100
Posaconazole	0.12-0.5	0.12		50	100	100	100	100
Ravuconazole	1-8	1		0	0	50	50	50
Voriconazole	2-8	2		0	0	0	50	50
Trichosporon spp. (2)
Amphotericin B	0.06-8	0.06		50	50	50	50	50
Itraconazole	8->8	8		0	0	0	0	0
Posaconazole	1->8	1		0	0	50	50	50
Ravuconazole	0.12->8	0.12		50	50	50	50	50
Voriconazole	0.05->8	0.5		0	50	50	50	50
Acremonium sp. (1)
Amphotericin B	2			0	0	0	100	100
Itraconazole	>8			0	0	0	0	0
Posaconazole	1			0	0	100	100	100
Ravuconazole	0.5			0	100	100	100	100
Voriconazole	0.5			0	100	100	100	100
Bipolaris sp. (1)
Amphotericin B	0.25			100	100	100	100	100
Itraconazole	0.25			100	100	100	100	100
Posaconazole	0.05			0	100	100	100	100
Ravuconazole	1			0	0	100	100	100
Voriconazole	0.5			0	100	100	100	100
Chrysosporium sp. (1)
Amphotericin B	0.06			100	100	100	100	100
Itraconazole	0.5			0	100	100	100	100
Posaconazole	0.12			100	100	100	100	100
Ravuconazole	>8			0	0	0	0	0
Voriconazole	>8			0	0	0	0	0
Geotrichum sp. (1)
Amphotericin B	0.25			100	100	100	100	100
Itraconazole	0.5			0	100	100	100	100
Posaconazole	0.25			100	100	100	100	100
Ravuconazole	0.06			100	100	100	100	100
Voriconazole	0.03			100	100	100	100	100
Wangiella dermatitidis (1)
Amphotericin B	1			0	0	100	100	100
Itraconazole	1			0	0	100	100	100
Posaconazole	0.06			100	100	100	100	100
Ravuconazole	1			0	0	100	100	100
Voriconazole	0.12			100	100	100	100	100