TABLE 1.
In vitro activities of five antifungal agents against 37 strains of zygomycetes
| Organism (no. of isolates) and agent | MIC (μg/ml)
|
|||
|---|---|---|---|---|
| Mean | Range | 50%a | 90%a | |
| Mucor spp. (7) | ||||
| POS | 1.54 | 0.125-8 | 0.5 | 1 |
| ITC | 2.18 | 0.25-8 | 1 | 2 |
| VRC | 59 | 32->64 | >64 | >64 |
| FLC | >64 | >64 | >64 | >64 |
| AMB | 0.24 | 0.06-0.5 | 0.25 | 0.25 |
| Rhizopus spp. (10) | ||||
| POS | 2.73 | 0.25-8 | 1 | 8 |
| ITC | 3.93 | 0.25-8 | 1 | 8 |
| VRC | 51.2 | 32->64 | >64 | >64 |
| FLC | >64 | >64 | >64 | >64 |
| AMB | 0.33 | 0.06-2 | 0.125 | 0.5 |
| Absidia coryambifera (5) | ||||
| POS | 0.13 | 0.03-0.25 | 0.03 | 0.25 |
| ITC | 0.14 | 0.03-0.25 | 0.06 | 0.25 |
| VRC | 48 | 16->64 | >64 | >64 |
| FLC | >64 | >64 | >64 | >64 |
| AMB | 0.30 | 0.25-0.5 | 0.25 | 0.25 |
| Cunninghamella spp. (5) | ||||
| POS | 0.36 | 0.03-1 | 0.25 | 1 |
| ITC | 0.60 | 0.125-2 | 0.25 | 0.5 |
| VRC | 43.2 | 8->64 | 16 | >64 |
| FLC | >64 | >64 | >64 | >64 |
| AMB | 0.55 | 0.125-2 | 0.25 | 0.25 |
| Apophysomyces elegans (4) | ||||
| POS | 1.57 | 0.03-4 | 0.25 | 2 |
| ITC | 2.63 | 0.03-8 | 0.5 | 2 |
| VRC | 44 | 16->64 | 32 | >64 |
| FLC | >64 | >64 | >64 | >64 |
| AMB | 0.33 | 0.03-1 | 0.03 | 0.25 |
| Cokeromyces recurvatus (2) | ||||
| POS | 2.13 | 0.25-4 | 0.25 | 4 |
| ITC | 4.13 | 0.25-8 | 0.25 | 8 |
| VRC | 40 | 16->64 | 16 | >64 |
| FLC | >64 | >64 | >64 | >64 |
| AMB | 0.31 | 0.125-2 | 0.125 | 2 |
| Saksenaea vasiformis (4) | ||||
| POS | 0.11 | 0.015-0.25 | 0.06 | 0.125 |
| ITC | 0.05 | 0.015-0.03 | 0.015 | 0.03 |
| VRC | 2.62 | 0.5-4 | 2 | 4 |
| FLC | 20.74 | 1-64 | 2 | 16 |
| AMB | 0.23 | 0.125-2 | 0.125 | 0.25 |
| All isolates (37) | ||||
| POS | 1.22 | 0.015-8 | 0.25 | 4 |
| ITC | 1.95 | 0.015-8 | 0.5 | 8 |
| VRC | 41.14 | 0.5->64 | >64 | >64 |
| FLC | 57.82 | 1->64 | >64 | >64 |
| AMB | 0.33 | 0.03-2 | 0.25 | 0.5 |
a
MIC at which 50% or 90% of the isolates were inhibited.