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. 2025 Dec 5;97(49):27091–27101. doi: 10.1021/acs.analchem.5c03754

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1H­(13C)-HMBC spectra of sodium naproxen (10 mM) obtained by IST reconstruction of NUS data and FT processing of uniform data. Spectra used 2 h of experimental time each. The sequential application of the TM and PSF polisher steps reduces larger artifacts in the reconstructions, particularly in regions prone to aliasing artifacts, such as at half the spectral window (dashed circled regions). A cross-section of the 13C dimension (see arrows on 2D plots) at the location of the circled artifacts shows in detail their progressive reduction with the TM and PSF polisher steps, where other noise spikes are seen to be reduced as well when using the TMPF schedule.