Table 1.

Inferred Hotspots: Single Analysis of Each Population

			Hotspot Position(s)c by Population
Gene	Sizea(kb)	Sb	AA	EA
AGTAP	18.543	63		2.406–3.406
ALOX5AP	32.08	134	2.409–3.909 and 8.409–10.659	8.909–10.409
ALOX12	16.822	57
ALOX15	13.205	67	1.189–3.439	1.439–3.939
APOH	20.067	82	17.435–19.185
C3	45.277	193	3.212–4.212, 13.462–16.212, and 36.212–39.212	3.212–4.212, 27.962–28.962, and 36.462–39.212
CAT	35.889	99	1.979–3.729
CD9	40.587	96	5.643–6.643
CD36	29.120	88		19.520–22.520
CHUK	5.364	22
CKM	19.934	42		7.774–10.524
CRF	9.929	22
CSF2	5.700	15
CSF3R	18.436	65
CYP4A11	13.598	69
DCN	39.164	107	19.849–20.849	20.052–20.052
F3	16.372	33
F5	74.814	216	36.130–39.130 and 42.630–45.630	32.130–34.630 and 41.630–43.130
F9	34.921	74	3.072–6.072
F10	28.545	55		23.401–24.651
F12	10.148	26
F13A1	178.078	121	2.252–3.752	2.252–3.752, 7.002–8.002, 74.002–77.002, and 147.752–150.752
GP1BA	6.093	19
HABP2	39.238	194	13.351–14.351 and 15.351–18.351	15.071–18.071 and 28.821–29.821
ICAM1	16.739	30
IFNAR1	33.935	94
IFNGR1	32.499	46
IFNGR2	35.946	62	10.451–13.451	28.451–29.451
IGF2AS	18.994	50
IL1R1	27.650	78	7.530–9.530 and 10.780–12.780
IL1R2	22.455	106	17.082–18.082	17.332–18.332
IL1RN	19.178	101	15.149–16.649
IL2RA	53.821	190	26.486–27.736	26.236–27.736 and 50.236–51.486
IL2RB	24.764	101	7.175–8.675	2.675–3.675
IL4R	26.231	119
IL5RA	42.815	152		.320–2.570, 18.820–20.320, and 23.820–26.820
IL6	7.498	28
IL7R	22.893	103
IL9R	15.045	57	1.961–2.961
IL10RB	35.634	143	15.090–15.340 and 29.340–31.340	2.356–3.856 and 14.356–15.356
IL11	9.324	27
IL11RA	9.732	16
IL12RB2	91.363	136	.634–3.634, 8.634–11.634, 21.634–24.634, 55.884–56.884, and 87.634–90.134	1.384–2.384
IL15RA	35.153	131		.122–1.122 and 26.122–27.122
IL16	20.028	62		15.172–16.172
IL17	6.158	22
IL20	6.030	13
IL21R	25.504	58	5.310–6.310, 7.560–10.060, and 13.560–14.560	3.560–4.810
IL26	33.365	98	28.203–31.203
IRAK4	32.369	78	27.439–28.939
ITGA2	104.312	236	8.860–11.860, 25.860–27.360, and 100.110–101.110	8.598–9.598
ITGA8	206.133	145	.107–2.607, 112.357–114.107	.357–3.107
JAK3	20.967	73
MAP3K8	30.917	89
MMP3	12.058	37	2.606–3.856
NFKBIA	44.703	92	19.000–20.750
NOS3	24.244	49
PLAUR	23.943	108	6.561–7.811, 13.061–14.311, 17.311–18.311, and 19.311–22.061	6.782–9.282
PLG	54.569	117	2.356–5.356	1.155–4.155
PLTP	17.934	31	11.493–12.743	11.743–12.743
PON1	28.959	104	5.062–6.562	5.312–6.312
PON2	30.882	85
PPARA	82.267	96	23.836–26.836
PPARG	148.541	121	142.553–145.553	145.800–146.809
PROC	11.867	36		3.861–4.861
PTGS1	28.043	92	5.425–7.425
RIPK1	39.985	87	12.337–13.837 and 33.337–34.337
SELE	13.825	62
SELL	24.384	98	12.833–15.083	14.117–15.617
SELP	43.717	122	20.427–23.427 and 28.427–31.427	21.677–22.927
SERPINA5	7.575	49	.106–1.606	.356–1.606
SFTPA1	23.895	114	11.052–12.552
SFTPA2	17.274	105	12.706–15.206	12.706–14.956
SFTPB	9.741	27	1.163–4.163	1.663–2.663
STAT3	76.609	97	9.050–10.050, 46.050–47.050, and 62.050–65.050
STAT6	18.638	32
TF	36.754	116
TFPI	38.066	93
THBS4	50.899	111		40.295–43.295
TIRAP	20.200	56
TNFAIP2	15.510	45
TNFRSF1A	15.115	34
TNFRSF1B	44.877	114	40.895–42.645	14.145–17.145 and 41.145–42.645
TRAF2	43.187	102	38.887–41.387	11.387–12.387 and 39.637–41.137
TRAF6	26.142	52
TRPV6	26.679	102	8.777–11.527
TTRAP	20.089	79	16.899–19.149
TYK2	31.650	97
VCAM1	22.293	54	12.375–15.375	12.125–15.125

^aSize is the amount sequenced between the first and last SNP (inclusive).

^bS denotes the number of SNPs across both populations.

^cHotspot positions are given (in kb) from the start of the region sequenced.