. 2005 Oct 5;77(5):851–868. doi: 10.1086/497705

Table 2.

Association Results for rs1861972 and rs1861973 in Additional Data Sets

	ParentalTransmissions^b		Allele inDSP Siblings^c
Data Set, SNP,^aand DiagnosticCriteria	Transmitted	Untransmitted	Affected	Unaffected	χ²Value^d	P Value^e
AGRE I^f:
rs1861972:
Narrow	383	354	202	185	4.991	*.0255*
Broad	467	436	253	226	5.861	*.0155*
rs1861973:
Narrow	373	338	199	183	6.936	*.0084*
Broad	449	415	242	220	6.297	*.0121*
AGRE II^g:
rs1861972:
Narrow	438	408	314	297	2.997	.0834
Broad	555	513	381	359	4.730	*.0296*
rs1861973:
Narrow	433	395	308	285	4.903	*.0268*
Broad	546	500	375	346	6.299	*.0121*
NIMH:
rs1861972:
Narrow	222	200	113	107	4.000	*.0455*
Broad	228	206	115	109	3.843	*.0500*
rs1861973:
Narrow	227	203	111	104	5.139	*.0234*
Broad	234	209	113	105	5.585	*.0181*

For rs1861972, the MAF was 0.269 and 0.317 in the AGRE II and NIMH data sets, respectively; for rs1861973, the MAF was 0.279 and 0.295, respectively.

The number of times the common allele was transmitted and not transmitted from parents to affected offspring.

The total number of occurrences of the common allele in affected siblings and unaffected siblings of DSPs.

Global χ² values calculated by PDTPHASE^sum (Dudbridge 2003).

P values generated by PDTPHASE^sum (1 df). P values in bold italics represent significant (P<.05) associations.

The initial 167 AGRE families (Gharani et al. 2004).

The additional 222 AGRE families.