Table 4.

Association Analysis for 14 Additional Polymorphisms in the AGRE I Data Set^a

	ParentalTransmissionsb		Allele inDSP Siblingsc
Polymorphismand DiagnosticCriteria	Transmitted	Untransmitted	Affected	Unaffected	χ2Valued	P Valuee
rs6150410:
Narrow	317	317	183	189	.081	.776
Broad	394	384	234	239	.043	.835
PvuII:
Narrow	253	249	127	131	.000	1.000
Broad	306	303	163	162	.025	.875
rs1345514:
Narrow	271	278	165	168	.220	.639
Broad	332	331	211	215	.015	.902
rs3735652:
Narrow	274	291	156	168	1.532	.216
Broad	350	357	203	220	.867	.352
rs6460013:
Narrow	467	466	249	246	.364	.546
Broad	568	569	314	309	.381	.537
rs7794177:
Narrow	425	414	239	237	1.374	.241
Broad	519	509	295	299	.237	.626
rs3824068:
Narrow	280	316	156	166	4.372	.036
Broad	355	384	205	215	2.664	.103
rs2361688:
Narrow	347	328	193	183	2.317	.128
Broad	423	394	243	224	4.208	.040
rs3824067:
Narrow	370	357	213	214	.581	.446
Broad	443	438	263	267	.003	.959
ss38341503:
Narrow	464	458	266	265	1.581	.209
Broad	565	559	334	332	1.684	.194
rs3808332:
Narrow	361	361	208	208	.000	1.000
Broad	433	440	260	261	.173	.677
rs3808331:
Narrow	421	417	243	245	.040	.841
Broad	519	510	309	310	.525	.469
rs4717034:
Narrow	365	362	205	212	.056	.812
Broad	436	444	257	267	.802	.370
rs3808329:
Narrow	424	405	229	243	.108	.742
Broad	516	491	289	303	.434	.510

^aThe initial 167 AGRE families (Gharani et al. 2004).

^bThe number of times the common allele was transmitted and not transmitted from parents to affected offspring.

^cThe total number of occurrences of the common allele in affected siblings and unaffected siblings of DSPs.

^dGlobal χ² values calculated by PDTPHASE^sum (Dudbridge 2003).

^eP values generated by PDTPHASE^sum (1 df). P values in bold italics represent significant (P<.05) associations.