TABLE 1.

Demographic and clinical features at the time of presentation of children with bacteremia due to either ESBL-producing or ESBL-nonproducing E. coli or K. pneumoniae

Characteristic	ESBL group (n = 49)	Non-ESBL group (n = 93)	P valuea
Sex (no. of males: no. of females)	27:22	54:39	0.79
Mean ± standard deviation age (yr)	4.58 ± 5.02	7.17 ± 5.97	0.01
Status or underlying disease (no. of episodes)
Hematological malignancy	22	44	0.77
Solid tumor	9	10	0.21
Steroid user	1	5	0.66
Preterm	6	6	0.24
Neonate	3	4	0.45
Othersb	8	18	0.66
Nonec	0	6	0.09
Focus of infection (no. [%] of episodes)	13 (27)	39 (42)	0.07
Pneumonia	6	7	0.35
Peritonitis	1	5	0.66
Urinary tract infection	3	8	0.75
Abscess	1	4	0.72
Cellulitis	0	5	0.72
Ascending cholangitis	2	6	0.72
Meningitis/acute otitis media/septic knee/typhlitis	0	1/1/1/1
Presenting condition at sepsis onset or presentationd
Shock	6/42	8/87	0.384
Hypothermia	2/42	2/87	0.596
Renal insufficiency	1/42	5/86	0.663
Hepatic dysfunction	9/41	25/86	0.397
Neurological dysfunction	1/41	1/87	0.540
Respiratory difficulty in case of pneumonia	0/6	0/7

^aAssociation was evaluated by Pearson's χ² test or Fisher's exact test for all parameters except age, which was compared by the Student t test.

^bOthers include biliary atresia (n = 8 episodes), chronic renal diseases (n = 3); chronic encephalopathy (n = 3); congenital neuromuscular diseases (n = 2); bronchopulmonary dysplasia (n = 2); chronic hepatitis (n = 2); failure to thrive (n = 2), and one episode each of congenital heart disease, Kasabach-Meritt syndrome, intestinal pseudo-obstruction with central venous catheter, and toxic shock syndrome.

^cThese six patients were associated with urinary tract infections (4 cases) or acute appendicitis (2 cases).

^dThe values represent the number of episodes with the indicated condition/total number of patients evaluated.