TABLE 2.
Effects of a selected flavone and a selected flavonol on the activities of streptococcal GTFs in solution and adsorbed onto an sHA surfacea
| Compound and concn (μM) | Mean % inhibition (SD)
|
|||||||
|---|---|---|---|---|---|---|---|---|
| GTF B
|
GTF C
|
GTF D
|
GTF Ss
|
|||||
| Solution | Surface | Solution | Surface | Solution | Surface | Solution | Surface | |
| Apigenin (flavone) | ||||||||
| 125 | 78.3 (4.8) | 31.8 (8.8) | 77.5 (4.2) | 30.0 (6.4) | 70.8 (4.9) | 17.0 (8.5) | 83.2 (6.1) | 13.8 (2.6) |
| 250 | 92.8 (4.2) | 40.0 (6.3) | 87.5 (3.2) | 42.1 (8.2) | 90.2 (3.6) | 25.5 (3.9) | 91.2 (4.6) | 20.2 (5.4) |
| 500 | 94.3 (3.7) | 55.5 (8.4) | 90.5 (3.8) | 60.5 (5.7) | 95.0 (2.6) | 33.0 (7.9) | 92.7 (3.9) | 30.0 (2.6) |
| Kaempferol (flavonol) | ||||||||
| 125 | 32.4 (5.6) | 9.9 (6.7) | 41.9 (3.2) | 24.2 (4.2) | 39.1 (1.8) | 20.4 (3.3) | 37.6 (5.7) | 9.7 (6.3) |
| 250 | 80.6 (3.5) | 27.8 (2.4) | 82.2 (2.7) | 25.8 (6.7) | 76.7 (5.8) | 23.5 (7.9) | 43.1 (3.3) | 8.8 (3.7) |
| 500 | 90.4 (1.2) | 40.2 (4.5) | 90.2 (2.1) | 35.2 (5.3) | 86.7 (4.2) | 28.5 (5.5) | 88.9 (3.7) | 19.2 (7.2) |
a
Percent inhibition was calculated by considering the control to have maximum GTF activity (100%).