TABLE 3.
Effects of a selected flavanone and a selected dihydroflavonol on the activities of streptococcal GTFs in solution and adsorbed onto an sHA surfacea
| Compound and concn (μM) | Mean % inhibition (SD)
|
|||||||
|---|---|---|---|---|---|---|---|---|
| GTF B
|
GTF C
|
GTF D
|
GTF Ss
|
|||||
| Solution | Surface | Solution | Surface | Solution | Surface | Solution | Surface | |
| Pinocembrin (flavanone) | ||||||||
| 125 | 3.7 (5.2) | 0.7 (3.3) | 0.0 (0.7) | 0.0 (0.0) | 1.5 (0.1) | 0.0 (0.7) | 25.7 (4.1) | 0.0 (0.2) |
| 250 | 7.2 (1.6) | 8.8 (4.3) | 8.5 (3.2) | 0.4 (0.1) | 4.8 (2.7) | 8.2 (2.7) | 32.6 (6.8) | 0.0 (4.2) |
| 500 | 15.9 (4.7) | 18.9 (5.4) | 17.2 (4.2) | 13.5 (4.9) | 14.9 (4.2) | 15.5 (6.2) | 45.7 (8.3) | 10.5 (2.7) |
| Pinobanksin-3-acetate (dihydroflavonol) | ||||||||
| 125 | 0.0 (0.8) | 9.4 (4.8) | 0.0 (0.0) | 0.0 (0.1) | 5.5 (4.5) | 0.0 (0.0) | 4.6 (5.7) | 0.0 (0.6) |
| 250 | 7.7 (3.5) | 7.3 (2.1) | 3.5 (4.2) | 0.0 (0.0) | 2.7 (3.3) | 4.5 (2.0) | 22.8 (3.6) | 0.0 (2.7) |
| 500 | 18.9 (2.8) | 10.3 (3.5) | 16.7 (4.3) | 0.0 (3.3) | 3.5 (2.1) | 10.1 (2.8) | 30.5 (7.2) | 9.9 (5.9) |
a
Percent inhibition was calculated by considering the control to have maximum GTF activity (100%).