TABLE 4.
MICs and MBCs of antibacterial compounds for S. mutans and S. sobrinus strainsa
| Test compound |
S. mutans UA159
|
S. mutans GS-5
|
S. sobrinus 6715
|
|||
|---|---|---|---|---|---|---|
| MIC | MBC | MIC | MBC | MIC | MBC | |
| tt-Farnesol (terpenoid) | 125 | 500 | 125 | 500 | 62.5 | 250 |
| Baicalein (flavone) | 500 | >500 | 500 | >500 | 500 | >500 |
| Flavanones | ||||||
| Pinocembrin | 250 | >500 | 250 | >500 | 250 | 500 |
| Sakuranetin | >500 | >500 | >500 | >500 | 500 | >500 |
| Isosakuranetin | 500 | >500 | 500 | >500 | 250 | >500 |
| Pinobanksin-3-acetate (dihydroflavonol) | 500 | >500 | 500 | >500 | 250 | >500 |
a
Values are micromolar concentrations. Chlorhexidine (positive control) had MICs of 1.1 to 2.2 μM (1 to 2 μg/ml) and an MBC of 8.9 μM (8 μg/ml). Kaempferide, kaempferol, galangin, isorhamnetin, rhamnetin, fisetin, rutin, apigenin, acacetin, chrysin, luteolin, tectochrysin, ferulic acid, p-coumaric acid, caffeic acid, β-caryophyllene, terpineol, syringaldehyde, protocatechuic acid, vanillin, benzoic acid, pinobanksin, and pinobanksin-7-methyl ether had MICs greater than 500 μM.