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Schematic illustration of the katG 200-bp fragment amplified with primers katG1F and katG4RB. Vertical thin arrows indicate HapII restriction sites (CCGG); the bold arrow marks codon 315, where the AGC→ACC transversion creates an additional HapII site in INHr M. tuberculosis strains. Horizontal double-headed arrows represent the principal HapII digestion products resulting from different katG codon 315 alleles.
