TABLE 1.

Clinical features of patients with complex CHD and heterotaxy.

Case	Sex	Age	Cardiovascular malformations	Other malformations
1809	M	7y2m	L/TGA	/
2247 a	F	2y10m	Dextrocardia, single ventricle, pulmonary atresia	/
2582 b	M	1y2m	Atrial situs ambiguity, single atrium, single ventricle, pulmonary atresia	/
2765	F	4y2m	Dextrocardia, single atrium, single ventricle, DORV, ASD, pulmonary stenosis	/
2962	F	0d	SI, VSD	/
3083	F	7m2d	Isolated levocardia, DORV, VSD, aorta anterior/IVC right of spine	/
3120	F	9y3m	Dextrocardia, functional single ventricle (tricuspid atresia), TGA, ASD, pulmonary stenosis	Shortened and partially absent right fourth rib
3167	M	6d	Dextrocardia, TGA, PDA, ASD, SI	Polydactyly, right accessory auricle, spine malformation
3718	M	4d	Isolated levocardia, TGA, VSD, ASD, pulmonary stenosis, right superior vena cava draining into the left atrium	/
3861	M	6y3m	TOF, left atrial isomerism	Pulmonary isomerism
3924	M	5y2m	Right atrial isomerism, single ventricle, AVSD, DORV, TGA, TAPVC, pulmonary stenosis, anomalous pulmonary venous drainage, right-side aortic arch	Asplenia
4066	F	3y2m	Isolated levocardia, DORV, VSD, ASD, pulmonary stenosis	/

ASD, atrial septa defect; AVSD, atrioventricular septal defect; DORV, double outlet right ventricle; IVC, inferior vena cava; L/TGA, L-transposition of the great arteries; PDA, patent ductus arteriosus; SI, situs inversus; TAPVC, total anomalous pulmonary venous connection; VSD, ventricular septal defect.

^a This patient underwent both CMA, and WES, but no pathogenic variants or likely pathogenic variants were identified.

^b This patient underwent WES, but no pathogenetic or likely pathogenic variants were identified.